The Buffalo Bills are coming off of their bye week and looking to end their two-game losing streak on Sunday against the Carolina Panthers.

The Bills are 4-2 and a couple of weeks ago, they lost to the Atlanta Falcons 24-14. Buffalo was down 21-7 at the half, got a touchdown back in the third quarter, but couldn't finish off the comeback. The Bills were 2-for-9 on third downs and lost in total yards 443-291. The rushing defense gave up 210 yards on the ground. The red zone offense was 2-for-3 and the red zone defense was 2-for-3. Time of possession was close, and the Bills turned the ball over twice. Quarterback Josh Allen went 15 of 26 for 180 yards, two touchdowns, and two interceptions.

The Panthers are 4-3 and just beat the New York Jets 13-6. It wasn't a pretty game on offense, but Carolina found a way to win against the winless Jets. They were good on fourth down and the one touchdown in the second quarter was the difference maker. The Panthers won in total yards, 302-220, and the red zone offense went 1-for-3. The red zone defense was 1-for-1, and they won in time of possession. The defense picked up two turnovers and Xavier Legette led the way on offense with nine catches for 92 yards and one touchdown.

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Note: The above data was collected on Oct. 24, 2025, and may have changed since writing.

Buffalo Bills

Carolina Panthers

Buffalo is currently 11th in passing yards, first in rushing yards, fourth in points scored, and 17th in points against. The offense was trending down and needed a much-needed break. Josh Allen is 7-0 after the bye week. The Bills will look to take care of the ball and get those passing yards up again. Also, the rushing defense ranks towards the bottom of the league standings, and it will need to be better against a good rushing team in the Panthers. Buffalo has a talented roster, ready to regain their form and end their two-game losing streak.

Carolina is currently tied for 26th in passing yards, third in rushing yards, tied for 23rd in points scored, and tied for 13th in points against. Quarterback Bryce Young has a high ankle sprain and is out for this game. Andy Dalton will be the starting quarterback. The Panthers' offense has been leaning on running back Rico Dowdle for the ground attack, and it's been a big part of their three-game winning streak. This team is playing with confidence, but two of those three wins were against some of the worst teams in the league.

Best Bet: Bills Spread

Buffalo is rested and ready to get back to putting up high numbers on offense. Carolina will be without their starting quarterback, and it might take a minute for Dalton to get going, which could help the Bills stack up the points. This game will come down to the Bills rushing defense vs. the Panthers rushing game.