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Yankees vs Red Sox Odds, Spread, and Total

The Yankees head into Fenway Park tonight with a chance to reset the rivalry and keep their grip on second place in the American League East. The Red Sox sit…

Aaron Judge #99 of the New York Yankees jogs to the dugout during the fifth inning against the Detroit Tigers at Yankee Stadium on September 11, 2025. Members of the New York Yankees were given permission by MLB to wear FDNY and NYPD hats tonight, honoring the fallen first responders of 9/11.
Elsa/Getty Images

The Yankees head into Fenway Park tonight with a chance to reset the rivalry and keep their grip on second place in the American League East. The Red Sox sit just a half-game behind heading into the three-game series. The first pitch is scheduled for 7:10 p.m. EST.

New York (81-65) snapped a brief skid with a 9-3 win over Detroit yesterday, while the Red Sox (81-66) dropped the finale of their West Coast trip to Oakland after winning three straight.

Luis Gil (3-1, 3.31 ERA) gets the start for New York, making his first appearance against Boston this season. The right-hander has allowed two runs or fewer in six straight starts.

He'll face Lucas Giolito (10-3, 3.38 ERA), a steady veteran presence for the Red Sox who got roughed up for four runs (two earned) in a five-inning start against Arizona last week.

Boston leads the rivalry 8-2 this season, winning eight straight before dropping the most recent matchup in late August. 

Spread

  • Yankees -1.5 (+130)
  • Red Sox +1.5 (-150)

Moneyline

  • Yankees -126
  • Red Sox +106

Total

  • Over 9 (+1--)
  • Under 9 (-120)

The above data was collected on Sept. 12, 2025, and may have changed since writing.

  • The Yankees have won 12 of their last 17 games but are just 1-8 in their last nine against the Red Sox.
  • The Red Sox are 6-4 against the spread in their last 10 matchups and 3-1 at home.
  • The Yankees are 4-6 against the spread in their past 10 games, including 3-2 on the road.
  • The Red Sox have won 13 of their last 20 games.
  • The total has gone over in 12 of the Yankees' last 18 games.
  • The under has landed in four of the Red Sox's last five games.

Yankees vs Red Sox Injury Reports

Yankees

  • Anthony Volpe, SS — Day to day (labrum).
  • Brent Headrick, RP — 15-day IL (forearm).

Red Sox

  • Romy Gonzalez, 1BB — Day to day (knee).
  • Dustin May, SP — 15-day IL (undisclosed).
  • Wilyer Abreu, RF — 10-day IL (calf).
  • Jordan Hicks, RP — 15-day IL (shoulder).
  • Richard Fitts, SP — 15-day IL (arm).
  • Luis Guerrero, RP — 60-day IL (elbow).

Yankees vs Red Sox Predictions and Picks

"Give me the Yankees to pick up the victory in the first game of the series. Gil has been impressive this season, and in his last start, he gave up only three hits and one run. Giolito, on the other hand, gave up four runs in his last start, and he's going to have some major issues here. The Yankees offense has all kinds of confidence after the way they played [yesterday] with their offense, and I expect a couple of home runs are going to be the difference here in this game. Back the Yankees." — Shane Mickle, Sports Chat Place

"Yankees starting pitcher Luis Gil has done a nice job keeping the ball in the park, allowing only two home runs across seven starts and 35.1 innings. However, he appears due for regression .... Red Sox starter Lucas Giolito has been solid over the past three months, with the Red Sox going 12–4 in his last 16 starts. Giolito has posted a 2.33 ERA with 0.9 home runs allowed per nine innings and is backed by a bullpen that ranks fifth in ERA since July 1 at 3.24. By contrast, the Yankees' bullpen ERA of 5.77 in that span ranks 29th. Pick: Red Sox." — Greg Peterson, VSiN

"Boston playing at home and having a starting pitcher in better form favors the Red Sox [today] against the Yankees. Giolito should be able to neutralize some of New York's power at the plate, while Yankees starter Gil has had control issues, which could result in multiple baserunners for Boston, as the Red Sox lineup is very patient at the plate. With Boston 44-28 at home and New York coming off back-to-back blowout losses, take the Red Sox. Final Score Prediction: Boston Red Sox win 6-3." — David Anicetti, Picks and Parlays